Publications

ME/CFS Network Publications

2021

Mathur, R., Carnes, M. U., Harding, A., Moore, A., Thomas, I., Giarrocco, A., Long, M., Underwood, M., Townsend, C., Ruiz-Esparza, R., Barnette, Q., Brown, L. M., Schu, M. (2021). mapMECFS: A portal to enhance data discovery across biological disciplines and collaborative sites. Journal of Translational Medicine, 19(1), 461. doi:10.1186/s12967-021-03127-3

Paul, B. D., Lemle, M. D., Komaroff, A. L., and Snyder, S. H. (2021). Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome. Proceedings of the National Academy of Sciences - PNAS, 118(34), 1. doi:10.1073/pnas.2024358118

Hanson, M. R. (2021, August 12). Are enteroviruses behind mysterious outbreaks of chronic fatigue syndrome? Frontiers Science News.

O'Neal, A. J., and Hanson, M. R. (2021). The enterovirus theory of disease etiology in myalgic encephalomyelitis/chronic fatigue syndrome: A critical review. Frontiers in Medicine, 8, 688486. doi:10.3389/fmed.2021.688486

E Komaroff, A. L., and Lipkin, W. I. (2021). Insights from myalgic encephalomyelitis/chronic fatigue syndrome may help unravel the pathogenesis of postacute COVID-19 syndrome. Trends in Molecular Medicine, 27(9), 895-906. doi:10.1016/j.molmed.2021.06.002

E Zhang, D. X., Vu, L. T., Ismail, N. N., Le, M., and Grimson, A. (2021). Landscape of extracellular vesicles in the tumour microenvironment: Interactions with stromal cells and with non-cell components, and impacts on metabolic reprogramming, horizontal transfer of neoplastic traits, and the emergence of therapeutic resistance. Seminars in Cancer Biology, 74, 24-44. doi.org/10.1016/j.semcancer.2021.01.007

Germain, A., Levine, S. M., and Hanson, M. R. (2021). In-depth analysis of the plasma proteome in ME/CFS exposes disrupted ephrin-eph and immune system signaling. Proteomes, 9(1), 6. doi:10.3390/proteomes9010006

2020

Nepotchatykh, E., Elremaly, W., Caraus, I., Godbout, C., Leveau, C., Chalder, L., Beaudin, C., Kanamaru, E., Kosovskaia, R., Lauzon, S., Maillet, Y., Franco, A., Lascau-Coman, V., Bouhanik, S., Gaitan, Y. P., Li, D., and Moreau, A. (2020). Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology. Scientific Reports, 10(1), 19620. doi:10.1038/s41598-020-76438-y

Giloteaux, L., O'Neal, A., Castro-Marrero, J., Levine, S. M., and Hanson, M. R. (2020). Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: A pilot study. Journal of Translational Medicine, 18(1), 387. doi:10.1186/s12967-020-02560-0

Lee, J., Vernon, S. D., Jeys, P., Ali, W., Campos, A., Unutmaz, D., Yellman, B., Bateman, L. (2020). Hemodynamics during the 10-minute NASA lean test: Evidence of circulatory decompensation in a subset of ME/CFS patients. Journal of Translational Medicine, 18(1), 314. doi:10.1186/s12967-020-02481-y

Milivojevic, M., Che, X., Bateman, L., Cheng, A., Garcia, B. A., Hornig, M., Huber, M., Klimas, N. G., Lee, B., Lee, H., Levine, S., Montoya, J. G., Peterson, D. L., Komaroff, A. L., and Lipkin, W. I. (2020). Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS. PloS One, 15(7), e0236148. doi:10.1371/journal.pone.0236148

Hanson, M. R., and Germain, A. (2020). Letter to the Editor of Metabolites. Metabolites, 10(5), 216. doi.org/10.3390/metabo10050216

Mandarano, A. H., Maya, J., Giloteaux, L., Peterson, D. L., Maynard, M., Gottschalk, C. G., and Hanson, M. R. (2020). Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations. The Journal of Clinical Investigation, 130(3), 1491-1505. doi:10.1172/JCI132185

Germain, A., Barupal, D. K., Levine, S. M., and Hanson, M. R. (2020). Comprehensive circulatory metabolomics in ME/CFS reveals disrupted metabolism of acyl lipids and steroids. Metabolites, 10(1), 34. doi:10.3390/metabo10010034

2019

Oh, J., and Unutmaz, D. (2019). Immune cells for microbiota surveillance. Science (American Association for the Advancement of Science), 366(6464), 419-420. doi:10.1126/science.aaz4014

Friedman, K. J., Bateman, L., Bested, A., and Nahle, Z. (2019). Editorial: Advances in ME/CFS research and clinical care. Frontiers in Pediatrics, 7, 370. doi:10.3389/fped.2019.00370

Komaroff, A. L. (2019). Advances in understanding the pathophysiology of chronic fatigue syndrome. JAMA : The Journal of the American Medical Association, 322(6), 499-500. doi:10.1001/jama.2019.8312

Other Publications

2019

Karhan, E., Gunter, C.L., Ravanmehr, V., Horne, M., Kozhaya, L., Renzullo, S., Placek, L., George, L., Robinson, P. N., Vernon, S. D., Bateman, L., Unutmaz, D. (2019). Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). bioRxiv 2019.12.23.887505. doi.org/10.1101/2019.12.23.887505

2018

Germain, A., Ruppert, D., Levine, S. M., and Hanson, M. R. (2018). Prospective biomarkers from plasma metabolomics of myalgic encephalomyelitis/chronic fatigue syndrome implicate redox imbalance in disease symptomatology. Metabolites, 8(4), 90. doi:10.3390/metabo8040090

Stevens, S., Snell, C., Stevens, J., Keller, B., and VanNess, J. M. (2018). Cardiopulmonary exercise test methodology for assessing exertion intolerance in myalgic encephalomyelitis/chronic fatigue syndrome. Frontiers in Pediatrics, 6, 242. doi:10.3389/fped.2018.00242

Nagy-Szakal, D., Barupal, D. K., Lee, B., Che, X., Williams, B. L., Kahn, E., Ukaigwe, J. E., Bateman, L., Klimas, N. G., Komaroff, A. L., Levine, S., Montoya, J. G., Peterson, D. L., Levin, B., Hornig, M., Fiehn, O., Lipkin, W. I. (2018). Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific Reports, 8(1), 10056. doi.org/10.1038/s41598-018-28477-9

Mandarano, A. H., Maya, J., Giloteaux, L., Peterson, D. L., Maynard, M., Gottschalk, C. G., and Hanson, M. R. (2020). Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations. The Journal of Clinical Investigation, 130(3), 1491-1505. doi:10.1172/JCI132185

2017

Nagy-Szakal, D., Williams, B. L., Mishra, N., Che, X., Lee, B., Bateman, L., Klimas, N. G., Komaroff, A. L., Levine, S., Montoya, J. G., Peterson, D. L., Ramanan, D., Jain, K., Eddy, M. L., Hornig, M., Lipkin, W. I. (2017). Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome, 5(1), 44. doi:10.1186/s40168-017-0261-y

Hornig, M., Gottschalk, C. G., Eddy, M. L., Che, X., Ukaigwe, J. E., Peterson, D. L., and Lipkin, W. I. (2017). Immune network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome with atypical and classical presentations. Translational Psychiatry, 7(4), e1080. doi:10.1038/tp.2017.44

Natelson, B. H., Mao, X., Stegner, A. J., Lange, G., Vu, D., Blate, M., Kang, G., Soto, E., Kapusuz, T., Shungu, D. C. (2017). Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity. Journal of the Neurological Sciences, 375, 411-416. doi:10.1016/j.jns.2017.02.046

Natelson, B. H., Vu, D., Coplan, J. D., Mao, X., Blate, M., Kang, G., Soto, E., Kapusuz, T., Shungu, D. C. (2017). Elevations of ventricular lactate levels occur in both chronic fatigue syndrome and fibromyalgia. Fatigue (Abingdon, Eng.), 5(1), 15-20. doi:10.1080/21641846.2017.1280114

Germain, A., Ruppert, D., Levine, S. M., and Hanson, M. R. (2017). Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism. Molecular BioSystems, 13(2), 371-379. doi.org/10.1039/c6mb00600k

2016

Hanson, M. R., Gu, Z., Keinan, A., Ye, K., Germain, A., and Billing-Ross, P. (2016). Association of mitochondrial DNA variants with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms. Journal of Translational Medicine, 14(1), 342. doi:10.1186/s12967-016-1104-5

Giloteaux, L., Hanson, M. R., and Keller, B. A. (2016). A pair of identical twins discordant for myalgic encephalomyelitis/chronic fatigue syndrome differ in physiological parameters and gut microbiome composition. The American Journal of Case Reports, 17, 720-729. doi:10.12659/AJCR.900314

Giloteaux, L., Goodrich, J. K., Walters, W. A., Levine, S. M., Ley, R. E., and Hanson, M. R. (2016). Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome, 4(1), 30. doi.org/10.1186/s40168-016-0171-4

E Hornig, M., Gottschalk, G., Peterson, D. L., Knox, K. K., Schultz, A. F., Eddy, M. L., Che, X., Lipkin, W. I. (2016). Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome. Molecular Psychiatry, 21(2), 261-269. doi:10.1038/mp.2015.29

Billing-Ross, P., Germain, A., Ye, K., Keinan, A., Gu, Z., and Hanson, M. R. (2016). Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome. Journal of Translational Medicine, 14(1), 19. doi:10.1186/s12967-016-0771-6

2015

Magnus, P., Gunnes, N., Tveito, K., Bakken, I. J., Ghaderi, S., Stoltenberg, C., Hornig, M., Lipkin, W. I., Trogstad, L., and Håberg, S. E. (2015). Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine. Vaccine, 33(46), 6173-6177. doi.org/10.1016/j.vaccine.2015.10.018

Natelson, B. H., Vu, D., Mao, X., Weiduschat, N., Togo, F., Lange, G., Blate, M., Kang, G., Coplan, J. D., and Shungu, D. C. (2015). Effect of Milnacipran Treatment on Ventricular Lactate in Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Trial. The Journal of Pain, 16(11), 1211-1219. doi.org/10.1016/j.jpain.2015.08.004

Hornig, M., Montoya, J. G., Klimas, N. G., Levine, S., Felsenstein, D., Bateman, L., Peterson, D. L., Gottschalk, C. G., Schultz, A. F., Che, X., Eddy, M. L., Komaroff, A. L., and Lipkin, W. I. (2015). Distinct plasma immune signatures in ME/CFS are present early in the course of illness. Science Advances, 1(1), e1400121. doi.org/10.1126/sciadv.1400121

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What is ME/CFS?

Myalgic Encephalomyelitis (ME), also referred to as Chronic Fatigue Syndrome (CFS), is a multi-system disease that causes dysfunction of the neurological, immune, endocrine, and energy metabolism systems.