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Individuals with ME/CFS, researchers, clinicians, and advocates committed to finding better diagnosis and treatment of the disease.

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Opportunities to Contribute

Status: Recruitment Completed

Together with subjects recruited and tested at the LA site, the Clinical Core of the Cornell ME/CFS Center at Ithaca College has met their goal of participation of 60 healthy individuals and 60 individuals with ME/CFS for a study investigating subject response to cardiopulmonary exercise tests.

The Clinical Core of the Cornell ME/CFS Center at Ithaca College is recruiting healthy individuals and individuals with ME/CFS to participate in cardiopulmonary exercise tests.

Status: Recruitment Completed

As part of the Cornell ME/CFS Center, Weill Cornell Medicine collected brain images from individuals with ME/CFS and healthy individuals to study oxidative stress and neuroinflammation, before and after an exercise challenge.

Status: Recruitment Completed

The total enrollment for the ETT study was 57 cases and 51 controls (108 total enrollment).

This study aims to assess the impact of exercise on the microbiome, the metabolome, the proteome, and the epigenome. Study participants, healthy individuals and individuals with ME/CFS, will undergo a supervised ETT with questionnaire, blood, stool, and saliva collections before and after testing at Columbia University.

This study will also recruit healthy individuals and individuals with ME/CFs at Stanford University. Details will be provided when available.

Columbia University Lean Test Study

Status: Recruitment Completed

Total enrollment for the Lean Test Study was 25 MECFS cases and 18 controls. There was an add on cohort of 40 Long-Covid cases (83 total enrollment).

This study aims to assess the clinical utility of the Lean Test as well as the impact of orthostatic stress on the metabolome and the epigenome. Study participants will complete a supervised Lean Test with a randomly selected subset of study participants providing blood samples before and after testing. ME/CFS patients, COVID-19 long haulers with PACS (post-acute COVID-19 syndrome) and healthy controls will be needed to complete this study.

Status: Recruitment Completed

Includes all subjects recruited and tested at the Bateman Horne Center (Clinical Core of the JAX ME/CFS Center). JAX has met their goal of participation of 93 healthy individuals and 150 individuals with ME/CFS (75 with illness duration of < 4 years and 75 with illness duration of >10 years. An additional cohort comprising of 35 subjects diagnosed with Post-Acute COVID-19 Syndrome (PACS, or long-COVID) have been enrolled, and samples are being received for follow-up timepoints for these subjects.

Grants that fund MECFSnet are managed by the National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases and the National Institute of Neurological Disorders and Stroke. This website was supported by a grant from NIH, grant #U24-NS-105535.

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Website design and development by RTI International. RTI is a registered trademark and trade name of Research Triangle Institute. The RTI logo is a registered trademark of Research Triangle Institute.

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What is ME/CFS?

Myalgic Encephalomyelitis (ME), also referred to as Chronic Fatigue Syndrome (CFS), is a multi-system disease that causes dysfunction of the neurological, immune, endocrine, and energy metabolism systems.